CHDH and cancer: To determine if the synthetic lethal (SL) relationship identified between CDH1 and allosteric inhibition of AKT was present in cancer cell lines, we tested the allosteric AKT inhibitors in an isogenic cell line pair derived from NCI-N87 gastric cancer cells: NCI-N87-WT and NCI-N87-CDH−/− (Supplementary Figure S1B).