Additionally, by the analysis of immunostained FTRHSP tissues for the expression of psoriasis-related skin protein markers, we observed that, compared with control tissues, the terminal differentiation process was perturbed, as demonstrated by increased expression of Ki67 (proliferation (data not shown)) and aberrant increase and expression of differentiation markers (filaggrin, K-10, involucrin, TGase-1, and junctional protein desmoglein-1) (Figure 8 and Figure 9, Figure S2). Here, PROS1 is linked to psoriasis.