GLP1R and metabolic syndrome: However, dipeptidyl peptidase-4 (DPP-4), which is ubiquitously expressed on most blood and tissue cells, has been shown to rapidly inactivate the GLP-1 secreted by L-cells, highlighting the potential application of proteolytically stable GLP-1 mimetics or DPP-4 inhibitors to treat type 2 diabetes, metabolic syndrome, and even nonalcoholic steatohepatitis [64].