PVT1 and neoplasm: When gemcitabine (25 mg/kg body weight once every four weeks) is used in combination with curcumin (100 mg/kg body weight daily) in pancreatic cancer BxPC3, MiaPaCa2 and Panc1 PDAC cells, it inhibited tumor growth thereby inhibiting expression of PRC2 subunit EZH2 and lncRNA PVT1. This combination also suppressed the spheroid-forming capability of tumor cells [309].