The increased early atherosclerosis in the aortic root of the CD1d−/−LDLR−/− mice was surprising since the Jα18−/−LDLR−/− have similar levels of atherosclerosis as the LDLR−/− and Aslanian and colleagues [25] reported a significant decrease in early aortic root atherosclerosis in CD1d−/−LDLR−/− mice compared to LDLR−/− mice. This evidence concerns the gene CD1D and atherosclerosis.