In the current study, we have investigated the effects of an increase or absence of endogenous iNKT cells on both lipoprotein metabolism and atherosclerosis by crossing Vα14 transgenic (Vα14tg) mice and Jα18 deficient (Jα18−/−) mice respectively with LDLR−/− mice and feeding the animals an atherogenic Western type diet (WTD). This evidence concerns the gene LDLR and atherosclerosis.