To establish the impact of acute changes in hyperlipidemia on the number or functional status of hepatic NKT cells, we compared NKT cell levels in the liver of female LDLR−/− and Vα14tg/LDLR−/− mice fed WTD for only 3 weeks (n = 2–4 per group). This evidence concerns the gene LDLR and hyperlipidemia.