Over-expression of Cx43 in DU145 and PC-3 cell lines enhanced pro-apoptotic effects induced by chemopreventive and chemotherapeutic agents such as se-methylselenocysteine (MSC) and docetaxel (DTX) [96,97], indicating that Cxs have the ability to modulate PCa cell growth by affecting the balance between cell proliferation and apoptosis. The gene discussed is GJA1; the disease is posterior cortical atrophy.