Numerous studies have proven that Notch signalling promotes obesity because it boosts gluconeo- and lipogenesis in the liver, leading to fatty liver disease [45]; induces the whitening of brown adipose tissue and insulin resistance in adipocytes [46]; and increases fat deposition in the hypothalamus by the activation of B cells (NF-κB) in mice on a high-fat diet [47]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.