CDH1 and familial pancreatic carcinoma: Whereas cancer cells featuring a complete EMT (i.e., E-cadherin downregulated at the transcriptional level) invaded the tumor microenvironment mostly as single cells, cells with internalized E-cadherin in a partial EMT state (E/M) migrate collectively as multicellular clusters which are also found in the blood of the pancreatic cancer mouse model [34].