TGFB1 and metabolic dysfunction-associated steatotic liver disease: More interestingly, these same findings were showed in type 1 diabetic patients with ultrasound-diagnosed NAFLD, confirming that NAFLD is involved in the pathogenesis of renal and retinal complications, probably through the release of pathogenic pro-inflammatory mediators such as advanced glycated end-products, reactive oxygen species (ROS), TNF-α, and TGF-β [30].