In conclusion, dysregulation of miRNA-193b-3p, 125b-5p, 150-5p involved in the regulation of genes with a role in the eicosanoid synthesis such as ALOX5 and PTGIS, and metalloproteinase/TIMP pathway, such as CX3CL1 are potentially implicated in the AAA pathogenesis. Here, ALOX5 is linked to triple-A syndrome.