Moreover, despite the initial reports of poor penetration of the blood brain barrier (BBB)[72], Nilotinib was later shown to be detectable in mouse brains upon oral and intraperitoneal administration[73,74] and to exhibit pronounced CNS efficacy with long-lasting responses in pre-clinical models of Parkinson’s disease[73] and in BCR-ABL+ CNS relapse CML patients[72]. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.