SCD and cancer: Another furoic acid derivative, 5-tetradecyl-oxy-2-furoic acid (TOFA), has been reported to reduce fatty acid synthesis by inhibiting acetyl coenzyme A carboxylase-α (ACCA), thereby increasing apoptosis rates and eradicating prostate cancer cells via the mitochondrial pathway.31 One study32 identified TOFA as a potent inhibitor of stearoyl coenzyme A desaturase 1 (SCD1), which is an enzyme in the fatty-acid synthesis pathway that depletes monounsaturated fatty acids and therefore restricts cancer cell proliferation.