We further excluded previously reported loci for T2D such as CDKAL1, ADCY5, BCAR1, HHEX/IDE, GCK, MTNR1B, and ANK1, and low birth weight remained associated with risk of T2D (OR, 1.75; 95% CI, 1.05-3.16; P = .04). This evidence concerns the gene ANK1 and type 2 diabetes mellitus.