FHIT is however downregulated in human pulmonary arterial hypertension (PAH), and FHIT positively regulates BMPR2 (bone morphogenetic protein receptor type 2), also downregulated in PAH, and important for the development of PAH (Dannewitz Prosseda et al., 2019). This evidence concerns the gene FHIT and pulmonary arterial hypertension.