Since this miRNA is abundantly expressed in hematopoietic tissues and mostly absent in non-hematopoietic ones (Chen et al., 2004), it is conceivable that HSUR2 would not be able to repress target mRNAs in non-hematopoietic tissues, curbing the ability of HVS to establish latent infections in non-hematopoietic tissues and thus defining the tropism of this virus’ latent infection. The gene discussed is MED23; the disease is disease arising from reactivation of latent virus.