Our results, achieved using 145 plasma samples from colorectal cancer (CRC) patients, patients carrying premalignant colorectal lesions, and controls, demonstrated that ΔNp73 showed a specific seroreactivity different from that of p73 with a higher diagnostic ability to discriminate between colorectal cancer patients, and controls, and especially premalignant individuals and controls which may have an important impact on cancer prevention to predict premalignant tumours. The gene discussed is TP73; the disease is cancer.