In this sense, further research is guaranteed to try to determine whether ∆Np73 seroreactivity would reflect chronic inflammation (like CEA or CA19-9) or whether it is more specific of colorectal premalignant lesions than that of CRC as our results suggest, and more importantly to assess the actual clinical management utility of ∆Np73 seroreactivity by determining its association with clinic-pathological parameters, which might help identifying patients with higher risk of cancer progression and also assist in selecting the most efficient personalized treatments. This evidence concerns the gene CEACAM5 and cancer.