DnaJb5, reduced by Trx1, is able to form a complex with class II histone deacetylases 4 (HDAC4) via intramolecular disulfide bonds in order to hinder HDAC4 nuclear export and thereby inhibit cardiac hypertrophy after ROS-generated hypertrophic stimuli60. The gene discussed is TXN; the disease is cardiac hypertrophy.