More specifically, Golgi-associated vesicle biogenesis, Clathrin-derived vesicle budding and the Rac-1 cell motility signaling pathway modules were enriched among the single-locus effects associated with PD at the same FDR applied to the discovery of BPMs (FDR ≤ 0.25; Supplementary Data 5). The gene discussed is RAC1; the disease is Parkinson disease.