TAT and Tyrosinemia type 1: Dysfunction of metabolic enzymes, fumarylacetoacetate hydrolase (FAH), tyrosine aminotransferase (TAT), and 4-hydroxyphenylpyruvic acid dioxygenase (HPD) in the phenylalanine and tyrosine catabolic pathway results in tyrosinemia type I, II, and III, respectively (Supplementary Fig. 1a).