Melanoma-specific expression of [HECTD2-AS]HERVH-2 was accompanied by loss of sense HECTD2 transcription (Fig. 5C), and a similar loss of the protein-coding sense transcript effect was mediated by antisense transcription of [HECTD2-AS]HERVH-3 in healthy bladder and BLCA (Supplemental Fig. S6), a pattern confirmed also in CCLE cell lines (Supplemental Fig. S7). Here, HECTD2 is linked to melanoma.