Examples include LTR-driven overexpression of proto-oncogenes, such as CSF1R overexpression in Hodgkin's lymphoma and anaplastic large-cell lymphoma (Lamprecht et al. 2010), or creation of truncated oncogenic forms of kinases through alternative splicing to an LTR element, such as anaplastic lymphoma kinase (ALK) in melanoma (Wiesner et al. 2015), and the erb-b2 receptor tyrosine kinase 4 (ERBB4) in ALK-negative anaplastic large-cell lymphoma (Scarfo et al. 2016). Here, ERBB4 is linked to melanoma.