PINK1 and Parkinson disease: In contrast to control DNLCs or fibroblasts from healthy subjects, NENF association with DJ-1 and PINK1 was disrupted at different degrees in the mt, ER, and MAM fractions of DJ-1 and PINK1 KO cells, in a manner analogous to that seen in the fibroblasts of subjects with PD with a PINK1 mutation (Figure 6F).