A number of studies suggest that a specific set of miRNAs exerts a genetic and epigenetic control during SLE pathogenesis.36 In particular, the up‐regulation of miR‐21, miR‐29b, miR‐30a, miR‐126 and miR‐148a and the down‐regulation of miR‐142‐3p/5p and miR146a, positively correlate with DNA methylation changes occurring in CD4+ T cells, which are responsible for their marked autoreactivity, one of the hallmarks occurring in SLE.37 The gene discussed is CD4; the disease is systemic lupus erythematosus.