The Eph receptor A4 (EPHA4), a member of the erythropoietin‐producing hepatocellular (Eph) family, promotes cell adhesion of multiple myeloma cells by enhancing the phosphorylation levels of Akt probably due to its interaction with CDK5.48 In our cellular system, the induction of EPHA4 in the hiPSC‐SLE line might influence the increase of pAkt levels. Here, EPHA4 is linked to systemic lupus erythematosus.