INS and Hypoglycemia: Comparing patients with and without an increase in asprosin levels during initial blood glucose lowering or hypoglycemia, patients with an increase of asprosin showed higher calculated whole-body insulin sensitivity (p = 0.050), and there were significant positive correlations between calculated whole-body insulin sensitivity and the calculated delta values of plasma asprosin between the hypoglycemic phase and the baseline (spearman correlation coefficient 0.664; p = 0.007, Fig 3B) as well as asprosin increase (spearman correlation coefficient 0.535; p = 0.04).