TNBC and HER2-positive BC patients who achieve a pCR to NAC have a good prognosis.[12] The improvement in outcomes pCR patients relative to non-pCR patients in this current study is consistent with the improvements in OS and event-free survival in pCR patients in other studies.[22–24] Although pCR patients have superior outcomes than non-pCR patients, a number of those with pCR still have disease recurrence and BC-related deaths. This evidence concerns the gene ERBB2 and breast cancer.