High levels of CHI3L1 in plasma in humans are associated with gastrointestinal cancer and risk of death.27, 28 Tarpgaard et al20 reported that the survival rate of colon cancer patients with high plasma levels of CHI3L1 was significantly lower than those of low plasma CHI3L1, indicating that CHI3L1 was a poor prognosis biomarker. Here, CHI3L1 is linked to colonic neoplasm.