ERBB2 and invasive breast carcinoma: Similar patterns were observed in a large validation dataset of > 8000 invasive breast cancers, where all PAM50 subtypes were bimodally distributed with a declining probability of late-onset from Luminal A to Luminal B to HER2-enriched to Basal-like, mirrored by an increasing probability of early-onset across these subtypes (Supplementary Fig. 4 and Supplementary Table 3).