A CpG mapping to HIP1 (cg15769835), an intergenic CpG on chromosome 15 (cg20123217), and another CpG mapping to LMAN2 (cg23483530) reached nominal significance in the replication cohort of MSA mixed-subtype cases when compared to controls (p < 0.05, Fig. 5). This evidence concerns the gene LMAN2 and multiple system atrophy.