When comparing MSA mixed-subtype cases and controls, six CpGs (cg15480237 in SENP6, cg15463989 in DGKI, cg02292205 in XKR6, cg22523351 in NSMAF, cg04222842 in SRP9, and cg09190141 in HTR3D; Supplementary Table S2.2, Online Resource 2) showed stronger and significant differences in the cerebellum only (absolute delta beta values ≥ 5%, FDR < 0.05). The gene discussed is SENP6; the disease is multiple system atrophy.