LMAN2 and multiple system atrophy: The LMAN2-cg23483530 showed significant changes in all three brain regions in the discovery MSA mixed-subtype cohort (FDR < 0.02, delta betas: − 13% cerebellum, − 10% frontal, and − 12% occipital lobe), and even surpassed a conservative Bonferroni significance threshold in the cross-region analysis (p = 3.6 × 10−8).