MOBP and progressive supranuclear palsy: Further supporting an involvement of MOBP in neurodegenerative diseases, several reports have provided evidence for a role of MOBP in the pathogenesis of multiple sclerosis [29], and genetic variants in MOBP have been associated with increased risk of neurodegenerative diseases, including progressive supranuclear palsy (PSP) and corticobasal degeneration [16, 21].