In three of those CpGs (cg04222842-SRP9, cg15737168-TECTA, cg00720065-intergenic chr 2), such strong effects were observed in the cerebellum but not in the frontal or occipital lobes (absolute delta beta values < 5% in the latter, Supplementary Table S2.1, Online Resource 2), suggesting these are region-specific DNA methylation changes in MSA. This evidence concerns the gene SRP9 and multiple system atrophy.