The closest coding gene upstream of the intergenic CpG on chromosome 15 (cg20123217, with increased DNA methylation levels in MSA) is VPS13C, which belongs to a family of large VPS13 proteins (VPS13A–D, vacuolar sorting proteins crucial for vesicular transport) and has been associated with early onset autosomal recessive PD [27]. The gene discussed is VPS13A; the disease is multiple system atrophy.