It is of note that one of the hub CpGs of the lightcyan module maps to INPP5A, which was also detected in our differential methylation analysis, both in the MSA mixed discovery cohort and in the MSA OPCA subtype (Table 2; Supplementary Tables S1.1–1.4, Online Resource 1). This evidence concerns the gene INPP5A and olivopontocerebellar atrophy.