In line with this, phagocytes, via ROS production, efficiently downregulated NKG2D and NKp46 (natural cytotoxicity receptor 1; also known as NCR1 or CD335) surface expression in vitro, which has been proposed to mediate NK cell deficiency in patients with acute myeloid leukemia [61]. The gene discussed is NCR1; the disease is acute myeloid leukemia.