We have recently shown that myeloid-specific expression of RORC1/RORγ marks advanced cancer stages [26] and orchestrates emergency myelopoiesis by suppressing negative (Socs3 and Bcl3) and promoting positive (C/EBPβ) regulators of granulopoiesis, as well as the key transcriptional mediators of myeloid progenitor commitment and differentiation to the monocytic/macrophage lineage (IRF8 and PU.1). The gene discussed is CEBPB; the disease is cancer.