To evaluate the effect of ITC supplementation on IR in T2DM and obese patients, we conducted a systematic review and meta-analysis to choose body mass index (BMI), fasting plasma glucose (FPG), fasting insulin (FI), HbA1c, homeostatic model assessment insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI) as the indices. The gene discussed is INS; the disease is type 2 diabetes mellitus.