Treatment with Chaihuang-Yishen Granule (CHYS), extracted from Radix Bupleuri, Radix Astragali, Rhizoma Dioscoreae nipponicae, Polyporus, Folium Pyrrosiae, and Hirudo, attenuated diabetic kidney injury through blockade of TGF-β1/Smad3-mediated renal fibrosis [71]. The gene discussed is TGFB1; the disease is renal fibrosis.