Research has shown that the active ingredient of crocus sativus, trans-crocetin, can contribute to the degradation of Aβ42 by mononuclear phagocytes in AD patients; this may be related to the increased expression of cathepsin (CatB) in mononuclear phagocytes of AD patients by trans-crocetin [15]. Here, TYRP1 is linked to Alzheimer disease.