In brief, crocin and resveratrol could significantly reverse the increased expression of CHOP and GRP78 in hippocampal tissues and PFC of AD rats (P < 0.05), indicating that crocin can alleviate endoplasmic reticulum stress in Hippo and PFC of AD rats and reduce the expression of GRP78 and CHOP. This evidence concerns the gene HSPA5 and Alzheimer disease.