In mechanism, aberrant circPRKCI inhibits the cellular proliferation, distant metastasis, and cell invasion in lung cancer by modulating the expression of markers of epithelial-to-mesenchymal transition, sponging miR-545 and miR-589, and relieving the inhibition of the protumor genic transcription factor E2F7 [44]. Here, E2F7 is linked to lung carcinoma.