ENO2 and lung carcinoma: Since current conventional serum biomarkers such as carcinoembryonic antigen, cytokeratin 19 fragments 21-1, and neuron-specific enolase are unsatisfactory in both sensitivity and specificity of early detection of lung cancer, circRNAs, with a pooled sensitivity and specificity of 0.8 and 0.8, respectively, are relatively hopeful indicators so as to contribute positively to the improvement in the early diagnosis with lung cancer.