FCGR2B and diabetic kidney disease: The mechanisms involved might include: (1) FcgRI is a high-affinity activity receptor that might play a major role in diabetic nephropathy by binding high numbers of IgG2 and oxidized LDL immune complexes that stimulate immune responses and downstream inflammation; (2) inhibitory receptor FcgRIIb was increased by feedback adjustment because the FcgRIII activation receptor was knocked out.