COL1A2 and osteoarthritis: Thus, we speculated that lnc-SAMD14-4 may contribute to OA by interacting with COL1A1 and COL1A2. Previous studies have used human primary chondrocytes treated with IL-1 β-treated to model the process of human osteoarthritis (Fu et al., 2015; Goldring et al., 1988).