TP53 and neoplasm: To validate the enhanced permeability and retention effects of nanoparticles in our Brca1Co/Co;MMTV-Cre;p53+/- model, we encapsulated the fluorescent dye Cy5 into nanoparticles using the same method as for Talazoparib and injected them i.v. into tumor-bearing BRCA-deficient mice.