Although no significant difference was observed in the percentage of CD4+ or CD8+ T cells in either the NanoTLZ or i.v. Talazoparib group in tumors, the percentage of Foxp3 positive cells around the tumor was significantly (p<0.01) decreased in the NanoTLZ group compared to saline controls (Figure 6D and quantified in Figure S8). This evidence concerns the gene CD4 and neoplasm.