A possible explanation for the discrepancy observed in the response between EGFR mutated TKI-sensitive PC-9P and TKI-resistant PC-9GR to Cav1 inhibition, may be acquisition of additional oncogenic changes in PC-9GR cells that may converge to tighten the Cav1-GLUT3 axis, which is also present in TKI-resistant EGFR mutated (H1975) and wild-type (H1703) NSCLC cells. The gene discussed is CAV1; the disease is non-small cell lung carcinoma.