Indeed, it has been reported that ZEB1 directly suppressed transcription of microRNA-200 family members miR-141 and miR-200c, which in turn targeted ZEB1 expression, revealing the pivotal role of the reciprocal repressive loop between ZEB1 and miR-141 and miR-200c in EMT and invasion of pancreatic, colorectal and breast cancer cells 26. This evidence concerns the gene ZEB1 and breast cancer.