TβR1 TD, a constitutively active mutant TGFBRI plasmid containing a substitution of threonine 204 with aspartic acid (T204D) that results in constitutive activation of TGF-β signaling in the absence of TGF-β stimulation 53, 54, was transfected into miR-33a-5p-overexpressing PCa cells. The gene discussed is TBR1; the disease is posterior cortical atrophy.