ZEB1 and posterior cortical atrophy: To explore the underlying mechanism of ZEB1 upregulation-mediated miR-33a-5p downregulation in bone metastatic PCa, we further analyzed the PCa dataset from TCGA, and found copy number gains of ZEB1 in 2/10 bone metastatic PCa tissues (20%), but that was not observed in any non-bone metastatic PCa (Figure 5D).