Consistent with this hypothesis, analysis of TCGA data deposited at proteinatlas.org (/ENSG00000204463-BAG6/pathology/tissue/ melanoma#12000001big) showed that the expression of BAG6 declined in melanomas with tumor progression and was significantly lower in metastatic stages III/IV compared to early stages (Figure 7A). The gene discussed is BAG6; the disease is neoplasm.