mRNA (Figure 2B-D) and protein (Figure 2E) levels of MTBP, MDM2, and p53 in TP53wt glioma cells were examined, and it was found that, at protein level, MTBP expression is positively correlated with MDM2 expression and negatively correlated with p53 expression (Figure 2E). The gene discussed is MDM2; the disease is glioma.