Additionally, Gal-3 deficiency significantly attenuated mRNA expression of FoxP3 and IL-10 (p<0.05 for IL-10; p<0.01 for FoxP3; Figure 4I) and remarkably reduced presence of renoprotective and immunosuppressive IL-10-producing, FoxP3 and STAT3-expressing regulatory T cells in CDDP-injured kidneys (Figure 4F-H, p<0.01) 56, indicating the important role of Gal-3 for generation of Tregs in CDDP-induced AKI. This evidence concerns the gene FOXP3 and acute kidney injury.