Serum levels of urea and creatinine (Figure S2A) and histological score (Figure S2B) were not significantly different between CDDP-treated WT recipients of TLR-2-primed WT and Gal-3-/-macrophages, suggesting that increased infiltration of M1 macrophages and decreased presence of M2 macrophages in damaged kidneys of CDDP-treated Gal-3-/- mice was just a reflection of the severity of AKI rather than its cause and that aggravated CDDP-induced AKI, seen in Gal-3-/- animals, developed due to the dysfunction of other Gal-3-expressing regulatory immune cells with nephroprotective function. Here, TLR2 is linked to acute kidney injury.