TLR2 and acute kidney injury: Gal-3-dependent nephroprotective effects of TLR-2-activated renal DCs has been relied on the IDO1-induced expansion of renal-infiltrating Tregs since either inhibition of IDO1 activity in TLR-2-primed renal DCs (Figure 8-9) or depletion of Tregs (Figure 11) completely diminished DCPam3CSK4-mediated attenuation of CDDP-induced AKI.