BAX and acute kidney injury: Accordingly, Gal-3 deficiency and reduced expression of TLR-2 increased susceptibility to CDDP-induced apoptosis (Figure 1D), while administration of rGal-3 significantly attenuated CDDP-induced AKI in Gal-3-/- mice by preventing Bax and caspase-3-dependent apoptosis (Figure 2E-H).