In order to confirm protective role of Gal-3 in CDDP-caused AKI, we analyzed the effects of Gal-3 inhibitor (Davanat) and recombinant Gal-3 (rGal-3) on the development of CDDP-induced acute renal failure in WT and Gal-3-/- animals. Here, LGALS3 is linked to acute kidney injury.