CD4 and acute kidney injury: Having in mind that crosstalk between renal-infiltrated neutrophils and Th17 cells as well as interaction between renal macrophages and Th1 cells have been implicated in the pathogenesis of AKI 54, 55, we analyzed phenotype and function of effector CD4+T cells in the CDDP-injured kidneys of WT and Gal-3-/- mice (Figure 4A-H).