CASP3 and acute kidney injury: Additionally, expression of pro-apoptotic Bax and caspase-3 were significantly higher and expression of anti-apoptotic Bcl-2 was significantly lower in the kidneys of CDDP+Davanat-treated WT mice compared to CDDP-only-treated WT animals (p<0.01; Figure 2D), confirming important anti-apoptotic role of Gal-3 in CDDP-induced AKI.