LGALS3 and acute kidney injury: CDDP treatment induced more severe tubular epithelial cell injury, tubular dilation, and intra-tubular cast formation in Gal-3-/- mice compared to WT animals (Figure 1C, lower panels), which resulted in significantly higher histological score (p<0.01, Figure 1B) in CDDP-treated Gal-3-/- mice, confirming that genetic deletion of Gal-3 remarkably aggravated AKI.