With a view to its application in remote-controlled moderate hyperthermia (41-43 °C), TRAIL was grafted onto clusters of iron oxide nanoparticles, further referred to as nanoclusters (NCs), and the ability of this original nanovector to induce selective apoptosis under MHT or PT was evaluated using isogenic TRAIL-resistant breast tumor cells, proficient or deficient for TRAIL receptors. The gene discussed is TNFSF10; the disease is breast neoplasm.