We found that CXCL12 was highly expressed in Hep3B cells but weakly detectable in the other four HCC cells (Figure S3G), and the inhibition of TCF12 expression in Hep3B cells led to decreased mRNA expression and protein secretion of CXCL12 (Fig 3D). This evidence concerns the gene CXCL12 and hepatocellular carcinoma.