In summary, this study has revealed that HNRNPA1 promotes cell growth via exosomal sorting of tumor suppressive miRNAs (mainly miR-320) in CML, while the secreted exosomes in turn function to remodel the niche to a leukemic favorable microenvironment via inhibiting osteogenesis of BMMSC (Figure 8E). The gene discussed is HNRNPA1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.