Moreover, CML-BC patients had a much lower miR-320 expression in intracellular levels but higher in plasma exosomal levels, compared to CML-CP patients (Figure 8C), which might be explained by the higher expression of HNRNPA1 in CML-BC cells. Here, HNRNPA1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.