ACTA1 and triple-A syndrome: Both qPCR (Figure 1A) and ISH (Figure 1B and Figure S2A) showed that the expression of lncRNA GAS5 was substantially higher in human AAA tissues than in the corresponding adjacent normal aortic tissues (p < 0.05) and was accompanied by a significant decrease in the number of HASMCs, as shown by α-SMA IHC (p < 0.05; Figure 1C-D) and western blot (p < 0.05; Figure 1E-F), a crucial pathological process that leads to AAA formation.