Moreover, AP-2α expression was negatively correlated with the expression of Nanog (Pearson correlation coefficient, -0.3963, P=0.0008; Figure 5G), Sox2 and CD133 (Pearson correlation coefficient, -0.4870 and -0.4714, P<0.001; Figure S4D) in glioma samples. This evidence concerns the gene PROM1 and central nervous system cancer.