STAT3 and central nervous system cancer: Because phosphorylated STAT3 could bind to the murine Nanog promoter and activate its transcription in ESCs 45, we also demonstrated that the expression of Nanog was slightly increased in the presence of IL6 in AP-2α overexpressing glioma cells, suggesting that STAT3 is partially involved in AP-2α-mediated Nanog expression and that certain overlaps and crosslinks exist between glioma stemness and drug resistance.