As reported 40-42, the expression levels of Nanog (paired Student's t-test; Figure S4A and Table S2), Sox2 (Figure S4B and Table S3) and CD133 (Figure S4C and Table S4) were significantly increased in glioma tissues compared with those in normal brain tissues, and their levels were especially increased in high-grade glioma tissues. Here, SOX2 is linked to central nervous system cancer.