Furthermore, our study presented a comprehensive molecular signature of EMT suppression upon STAT3 deletion and highlighted the down-regulation of transcription factors involved in EMT, such as SNAI2, ZEB1/2, TWIST1/2, ETS1 and FOXC1. These observations strongly suggest that STAT3 contributes to EMT progression in ovarian cancer. The gene discussed is ZEB1; the disease is ovarian carcinoma.