We found that expression of KLF5 protein was down-regulated by the p70S6K inhibitor (Figure 2G), suggesting that p70S6K could promote KLF5 expression by enhancing initiation of its mRNA translation in prostate cancer cells and KLF5 could mediate p70S6K function in autophagy. The gene discussed is KLF5; the disease is Familial prostate cancer.