The TGF-β1/smad signalling pathway can regulate liver homeostasis [9], although the distinct role of TGFBR2 and TGFBRAP1 in the TGF-β1/smad signalling pathway had been observed previously, playing a vital role in liver fibrosis and hepatocarcinogenesis [9]. This evidence concerns the gene TGFBRAP1 and Hepatic fibrosis.