Therefore, as the important role of TGFBRAP1 and TGFBR2 in the signalling pathway, genetic gene polymorphisms of TGFBRAP1 and TGFBR2 have been researched in hepatocellular carcinomas and hepatitis C infection, which indicated that genetic polymorphisms of TGFBRAP1 and TGFBR2 may disturb the regulation in liver injury and renewal [11–13]. Here, TGFBRAP1 is linked to hepatocellular carcinoma.