Consequently, elevated levels of cFLIP in tumor tissues from patients with a variety of cancers including lung cancer, Burkitt’s lymphoma, cervical caricinoma and colorectal carcinoma are correlated with poor clinical outcomes41–44, implicating the existence of a strong association between suppression of DISC-mediated apoptosis by cFLIP and tumorigenesis. This evidence concerns the gene CFLAR and lung cancer.